Subscription to Chronobiology International – Special rate for ISC members
The special rate is offered to members who paid the annual dues.
Please enter the ISC web site and click on menu item "Journal – Books". The page will open. Click on "Chronobiology International". The informa site will open. Click on "News & offers" (left side of the page). Another page will open. Click on "Special rates for the ISC". The subscription form will appear. Be so kind to fill the form.
Previous Announcements
DISRUPTION OF THE CIRCADIAN SYSTEM DUE TO SHIFTWORK IS PROBABLY CARCINOGENIC IN HUMANS
The International Agency for Research on Cancer (IARC), an institution of the World Health Organization, has recently appointed a Working Group to evaluate the epidemiologic and supportive experimental evidence in regards to the potential carcinogenicity of shiftwork. On October 2007, after 10 days of intense working sessions in Lyon (France), the Working Group (which included representatives of the WHO, the NIH, NCI and the European Union) composed the final summary statement, which will read that “there is sufficient evidence in experimental animals for the carcinogenicity of light during the daily dark period (biologic night)” and that “shiftwork that involves circadian disruption is probably carcinogenic in humans”.
The section on shiftwork had four subsections. The first “Definition and Occurrence of Exposure” was chaired and reported by Giovanni Costa from Milan (Italy), with a report on biomarkers by Scott Davis from Seattle (WA). The second “Cancer in humans” was chaired by Eva Schernhammer (Harvard University), with reports by Jonni Hansen (Danish Cancer Society), Eeno Pukkala (Finnish Cancer Registry), and Richard Stevens (University of Connecticut). The third “Cancer in Experimental Animals” was chaired by David Blask (Basset Healthcare Research Institute, Cooperstown, NY), with input by Francis Levi (Villejuif, France) and Chris Poitier (NIH). The fourth on “Mechanistic and other Data” was chaired and reported by Erhard Haus (University of Minnesota) in regards to melatonin and neuroendocrine immune modulation with input by Yong Zhu (Yale University) in regards to molecular mechanisms. Additional input came from Dave Blask on peripheral hormone interactions, and Josephine Arendt in regards to melatonin. Emphasis was on the melatonin suppression by light during the night, and the immune deficiency experienced both with lack of melatonin and with sleep deprivation which is characteristic for shiftwork.
The complete report of the Working Group will be published as Volume 98 of the IARC Monographs (in press).
For more details see the short report by Erhard Haus on shiftwork, light and cancer, which will be published in Chronobiology International, issue 24(6) – December, 2007.
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